Vedanta Biosciences Granted Three U.S. Patents Broadly Covering Pharmaceutical Compositions and Methods of Use for Therapeutics Based on Immune-Modulating Bacterial Consortia
CAMBRIDGE, Massachusetts, May 16, 2017— Vedanta Biosciences, pioneering the development of a novel class of therapies for immune and infectious diseases based on rationally designed consortia of bacteria derived from the human microbiome, today announced that the United States Patent and Trademark Office (USPTO) has issued three new patents, 9,642,881, 9,642,882, and 9,649,345. The patents broadly cover compositions of matter and methods of use for therapeutic products based on beneficial clostridium bacteria, further strengthening Vedanta’s leading intellectual property position.
“Our pioneering efforts in the development of therapeutics based on immune-modulating bacterial consortia are continuing to be validated through the issuance of additional composition of matter and method of treatment claims worldwide,” said Bernat Olle, Ph.D., Chief Executive Officer of Vedanta Biosciences. “The expansion of our intellectual property estate and, in particular, these new patents significantly enhance the value proposition for our pipeline and partnered programs.”
The new U.S. patent issuances provide additional support for several programs in Vedanta’s pipeline, including therapies for the treatment of Inflammatory Bowel Disease (IBD) and other autoimmune and infectious diseases. They also build on earlier patent issuances from the USPTO, European Patent Office (EPO), and Japan Patent Office (JPO) to further enhance Vedanta’s global intellectual property portfolio.
About Vedanta Biosciences
Vedanta Biosciences, a subsidiary of PureTech Health (LSE: PRTC; www.puretechhealth.com), is pioneering development of a novel class of therapies for immune and infectious diseases based on rationally designed consortia of bacteria derived from the human microbiome, with clinical trials expected to begin in 2017. Founded by PureTech Health and a group of world-renowned experts in immunology and microbiology, Vedanta Biosciences is a leader in the microbiome field with capabilities to discover, develop and manufacture drugs based on live bacterial consortia. Leveraging its proprietary technology platform and the expertise of its team of scientific co-founders, Vedanta Biosciences has isolated a vast collection of human-associated bacterial strains and characterized how the immune system recognizes and responds to these microbes. This work has led to the identification of human commensal bacteria that induce a range of immune responses – including induction of regulatory T cells and Th17 cells, among others – as well as the characterization of novel molecular mechanisms of microbial-host communication. These advances have been published in leading peer-reviewed journals including Science, Nature (multiple), Cell and Nature Immunology. Vedanta Biosciences has harnessed these biological insights as well as data from clinical translational collaborations to generate a pipeline of programs in development for infectious disease, autoimmune disease, inflammation and immune-oncology. The clinical potential of therapeutic manipulation of the microbiome has been validated by multiple randomized, controlled trials in infectious disease and inflammatory bowel disease. Vedanta Biosciences has a leading global intellectual property portfolio in the microbiome field with patents issued by the European Patent Office (EPO), Japan Patent Office (JPO) and the United States Patent and Trademark Office (USPTO), and through patent families exclusively licensed worldwide to Vedanta under an agreement with the University of Tokyo.
Vedanta Biosciences’ scientific co-founders have pioneered the fields of innate immunity, Th17 and regulatory T cell biology, and include Dr. Ruslan Medzhitov (Professor of Immunobiology at Yale), Dr. Alexander Rudensky (tri-institutional Professor at the Memorial Sloan-Kettering Institute, the Rockefeller University and Cornell University), Dr. Dan Littman (Professor of Molecular Immunology at NYU), Dr. Brett Finlay (Professor at the University of British Columbia) and Dr. Kenya Honda (Professor, School of Medicine, Keio University). Vedanta is backed by PureTech Health, Seventure, Invesco Asset Management, and Rock Springs Capital.
Forward Looking Statement
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