A Foundational Intellectual Property Estate In The Human Microbiome Field

Vedanta has developed a key Intellectual Property (IP) portfolio in the human microbiome field. The portfolio includes fundamental patents (the “Honda patents”) covering compositions and therapeutic uses of products containing bacteria belonging to Clostridium clusters IV and XIVa, as well as spore-forming fractions obtained from stool samples. The European Honda patent EP2575835 was recently upheld in opposition proceedings at the EPO (View Press Release). Bacteria within clusters IV and XIVa are among the most abundant colonizers of the human intestine and they play an important role in human health, including regulating immune responses. Our IP estate includes issued patents in the major pharmaceutical markets (US, Europe, and Japan) with priority dates going back to 2010. Our patents provide coverage through at least 2031, with some patents extending coverage through at least 2037. This Intellectual Property portfolio puts Vedanta in a unique leadership position in the microbiome field and allows us to support our internal programs as well as enable our partners to advance bacterial consortia therapeutics.

Vedanta’s European and U.S. Patents

Patent	Title	Applicant/Assignee	Country	Issue Date
EP3539548	Composition for Inducing Proliferation or Accumulation of Regulatory T Cells	The University of Tokyo	EP	Apr 29, 2020
EP3552613	Composition for Inducing Proliferation or Accumulation of Regulatory T Cells	The University of Tokyo	EP	Apr 29, 2020
EP3178483	Composition for Inducing Proliferation or Accumulation of Regulatory T Cells	The University of Tokyo	EP	Apr 29, 2020
10,624,933	Human-Derived Bacteria That Induce Proliferation or Accumulation of Regulatory T Cells	The University of Tokyo; School Corporation, Azabu Veterinary Medicine Educational Institution	US	Apr 21, 2020
EP2785828	Human-Derived Bacteria That Induce Proliferation or Accumulation of Regulatory T Cells	The University of Tokyo; School Corporation, Azabu Veterinary Medicine Educational Institution	EP	Apr 08, 2020
10,588,925	Composition for Inducing Proliferation or Accumulation of Regulatory T Cells	The University of Tokyo	US	Mar 17, 2020
10,576,136	Compositions and Methods for the Induction of CD8+ T-Cells	Keio University; The University of Tokyo	US	Mar 03, 2020
10,555,978	Composition for Inducing Proliferation or Accumulation of Regulatory T Cells	The University of Tokyo	US	Feb 11, 2020
10,555,980	Treatment of Clostridium Difficile Infection	Vedanta Biosciences Inc.	US	Feb 11, 2020
10,507,221	Methods and Compositions for the Treatment of Food Allergy	Vedanta Biosciences Inc.	US	Dec 17, 2019
10,456,431	Treatment of Clostridium Difficile Infection	Vedanta Biosciences Inc.	US	Oct 29, 2019
10,350,250	Treatment of Clostridium Difficile Infection	Vedanta Biosciences Inc.	US	Jul 16, 2019
10,342,832	Human-derived Bacteria that Induce Proliferation or Accumulation of Regulatory T Cells	The University of Tokyo; School Corporation, Azabu Veterinary Medicine Educational Institution	US	Jul 09, 2019
10,328,108	Composition for Inducing Proliferation or Accumulation of Regulatory T Cells	The University of Tokyo	US	Jun 25, 2019
10,322,150	Composition for Inducing Proliferation or Accumulation of Regulatory T Cells	The University of Tokyo	US	Jun 18, 2019
10,300,137	Compositions and Methods for Induction of TH17 Cells	Riken; The University of Tokyo; School Corporation, Azabu Veterinary Medicine Educational Institution	US	May 28, 2019
10,183,045	Human-Derived Bacteria That Induce Proliferation Or Accumulation Of Regulatory T Cells	The University of Tokyo; School Corporation, Azabu Veterinary Medicine Educational Institution	US	Jan 22, 2019
10,130,695	Compositions Containing Combinations Of Bioactive Molecules Derived From Microbiota For Treatment Of Disease	Vedanta Biosciences Inc.; Riken	US	Nov 20, 2018
10,092,603	Composition For Inducing Proliferation Or Accumulation Of Regulatory T Cells	The University of Tokyo	US	Oct 09, 2018
10,064,904	Treatment Of Clostridium Difficile Infection	Vedanta Biosciences Inc.	US	Sep 04, 2018
10,058,578	Human-Derived Bacteria That Induce Proliferation Or Accumulation Of Regulatory T Cells	The University of Tokyo; School Corporation, Azabu Veterinary Medicine Educational Institution	US	Aug 28, 2018
10,052,353	Human-Derived Bacteria That Induce Proliferation Or Accumulation Of Regulatory T Cells	The University of Tokyo; School Corporation, Azabu Veterinary Medicine Educational Institution	US	Aug 21, 2018
9,999,641	Treatment Of Clostridium Difficile Infection	Vedanta Biosciences Inc.	US	Jun 19, 2018
9,833,483	Composition For Inducing Proliferation Or Accumulation Of Regulatory T Cells	The University of Tokyo	US	Dec 05, 2017
9,827,276	Composition For Inducing Proliferation Or Accumulation Of Regulatory T Cells	The University of Tokyo	US	Nov 28, 2017
9,808,519	Composition For Inducing Proliferation Or Accumulation Of Regulatory T Cells	The University of Tokyo	US	Nov 07, 2017
9,801,933	Composition For Inducing Proliferation Or Accumulation Of Regulatory T Cells	The University of Tokyo	US	Oct 31, 2017
9,764,019	Compositions Containing Combinations Of Bioactive Molecules Derived From Microbiota For Treatment Of Disease	Vedanta Biosciences, RIKEN	US	Sep 19, 2017
9,662,381	Composition for Inducing Proliferation Or Accumulation Of Regulatory T Cells	The University of Tokyo	US	May 30, 2017
9,649,345	Human-Derived Bacteria That Induce Proliferation Or Accumulation Of Regulatory T Cells	The University of Tokyo; School Corporation, Azabu Veterinary Medicine Educational Institution	US	May 16, 2017
9,642,882	Composition For Inducing Proliferation Or Accumulation Of Regulatory T Cells	The University of Tokyo	US	May 09, 2017
9,642,881	Human-Derived Bacteria That Induce Proliferation Or Accumulation Of Regulatory T Cells	The University of Tokyo; School Corporation, Azabu Veterinary Medicine Educational Institution	US	May 09, 2017
EP2575835	Composition For Inducing Proliferation Or Accumulation Of Regulatory T Cells	The University of Tokyo	EP	Oct 19, 2016
9,433,652	Composition For Inducing Proliferation Or Accumulation Of Regulatory T Cells	The University of Tokyo	US	Sep 06, 2016
9,421,230	Composition For Inducing Proliferation Or Accumulation Of Regulatory T Cells	The University of Tokyo	US	Aug 23, 2016
9,415,079	Composition For Inducing Proliferation Or Accumulation Of Regulatory T Cells	The University of Tokyo	US	Aug 16, 2016