RESEARCH ASSOCIATE, IMMUNOLOGY
Vedanta is pioneering the development of a new class of therapies that act by modulating the human microbiome. Modulation of the human microbiota holds enormous promise to treat a broad range of immune, infectious, and metabolic diseases in ways that are completely different to existing drug classes. Breakthrough discoveries of our scientific team in the field of mucosal immunology have led to the first rationally designed drug candidates in the microbiome field. Vedanta was founded by PureTech Ventures and a team of world renowned experts in immunology and microbiology.
Position Description / Responsibilities
The candidate will conduct in vivo studies designed to assess the ability of commensal bacteria to induce immune responses in germ-free and conventional mice. The principal activities of this role will be to develop assays to evaluate molecular and cellular pathways of host-microbe interactions, execute high-throughput screens, and perform in vivo experimental procedures using mouse models. Responsibilities also include the culturing and phenotypic characterization of human and murine primary immune cells. The job title and level will correspond to the experience and skills of the selected candidate.
- Bachelors or Masters Degree in a biological science;
- 2+ years research experience in immunology;
- Experience using basic immunological techniques (flow cytometry, ELISA, cell culture and phenotypic characterization of primary immune cells) as well as molecular biology methods (DNA/RNA isolation and analysis, PCR/qPCR);
- Highly motivated and organized individual with good communication skills;
- Team player, able to work well in a group setting in a fast paced environment.
- Expertise in animal models of autoimmunity and inflammation, particularly gastrointestinal inflammatory diseases.
- Animal handling experience including gastrointestinal lavage and IP injection.
- Experience with dissection of mouse intestine and isolation of cells from mouse intestinal tissue.
- General understanding and interest in the field of the human microbiome.